https://www.cureadlab.com/sadowski-lab-home daily 1.0 2026-03-30 https://www.cureadlab.com/about daily 0.75 2025-05-09 https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/6312d53f-0669-4502-90ea-86fe23c1f9cf/Labeled+AB+in+E2+E3+E4.png About (original) Amyloid plaque deposition is lowest in Alzheimer's transgenic mice with the ApoE2 allele, followed by ApoE3, with ApoE4 mice having the greatest amyloid burden, consistent with what is observed in ApoE4 human carriers (Pankiewicz et al., 2017) https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/1daa69ba-9b0c-4e9c-99e0-db036e4ced1d/Labeled+GFAP%2C+C3+-+confocal.png About (original) Astrocytes (GFAP) are more likely to display a neurotoxic (C3) phenotype following prion infection when mice lack ApoE, pointing to a role of ApoE in suppressing neurotoxic astrocyte presentation (Pankiewicz & Lizinczyk et al., 2021) https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/91dc9d84-ed85-48fe-8dd7-32ba8b09d5c8/Labeled+Cathespin+D+Prion.png About (original) Prion monoclonal antibodies highly co-localize with a marker of lysosomal activity in vitro, suggesting mAb-Prion complexes are degraded by lysosomes (Pankiewicz et al., 2019) https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/88322853-0e5f-44ef-b918-e6382bf0eba0/Spines4+w+labels.png About (original) Immature (green) dendritic spines are most abundant in ApoE4 mice and mature (red) dendritic spines are most abundant in ApoE2 mice (Diaz et al., 2022) https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/ea370c5f-585b-4881-bcda-1ebcdb1fe52a/Labeled+Iba1%2C+CD68+confocal.png About (original) Microglia (Iba1) express low levels of phagocytic markers (CD68) after prion infection in ApoE knockout mice, indicating ApoE may be needed for effective phagocytic activity in microglia (Pankiewicz & Lizinczyk et al., 2021) https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/cb020ed9-13ae-4a53-b21b-307fad7b1e87/Prdx6+x+34+gfap+AB+labeled.png About (original) In mice overexpressing Prdx6, astrocytes tightly surround amyloid plaques, likely for direct engagement or for guiding microglial processing of plaques (Pankiewicz et al., 2020) https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/a40be505-388d-425f-a935-0f2e5d19588e/CAR+Graphic.PNG https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/af41e759-d7db-469a-aa60-cb3033c40103/MGnD+and+A1+in+PrP+ApoE+KO.PNG https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/019d4292-4f22-487d-a6e0-7019ced6a84c/Iba1.jpg https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/7b385fb0-6b3f-4d31-bfc3-1ad335146a62/PRDX6+AB+and+Glial+Activity.PNG https://www.cureadlab.com/sadowski-lab-team daily 0.75 2026-03-27 https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/ceee0984-a65b-4d69-a375-6a568d869965/204A8690-Edit.jpg https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/64546cc6-04c5-4674-8151-651c4dd1ab72/IMG_3841.png https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/5de581f5-e287-4544-88eb-b092e102edc6/thumbnail_image.png https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/05900519-77a6-4527-a1fd-f2195e7b9dd0/Princess%2CT+photo.jpg https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/043f67cc-c5d8-47b4-939e-c68f5af74151/1000032669.jpg https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/59744594-2152-45cc-924c-4b3afedb503b/Jenny.PNG https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/30a845d0-b4ad-4aaf-814b-b9a62a43edd8/Mitchell.PNG https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/1855237f-90b2-4a20-99ea-2a548edffd30/Leor.PNG https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/3a9589ee-37b0-44fa-b173-d1b9719c267c/Marisol.PNG https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/a2ed9d09-6ec8-41aa-93f2-55c60f245419/Cassidy.PNG https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/ae4a0d10-2f6f-4f3e-9be8-b6cd4b36f4d1/Sandrine.PNG https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/4c56efbc-e75e-4c21-beab-fa7cab04e224/Maitea.jpg https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/b014081e-de81-4bf8-b932-067745c508c1/Ayodeji.PNG https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/d6084cb7-21c3-46cc-b901-1983fde45019/Magda+2.jpg https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/c8b16cb8-4c0f-4878-8ffc-fcdc8cd09796/Arjel.PNG https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/4f75fa6d-e39e-469f-a2e3-34b6ba6fc59c/Malgorzata.PNG https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/a3f1be4d-6182-44b9-b03e-19e17c4883d8/Roman.PNG https://www.cureadlab.com/sadowski-lab-support daily 0.75 2025-05-09 https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/bd8b697a-9906-4db0-b6a4-736781abbdf6/Fisher+icon.jpg https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/970b713a-ec7e-41bf-9196-0da055275557/NIH+Icon.png https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/93579cee-829b-4d17-a997-8e37fe6700cd/NIA+icon.png https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/5f611e91-5c51-4a12-b26e-5400646032e1/Alz+Assoc.PNG https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/6a7177c4-0feb-4aa8-a8e5-ad989fe7c39f/AFAR.PNG https://www.cureadlab.com/sadowski-lab-publications daily 0.75 2026-03-24 https://www.cureadlab.com/contact-the-sadowski-lab daily 0.75 2026-03-30 https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/287c3998-ac62-4040-b1fa-fedde44b3a23/Favicon+Text.png https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/751cafd7-d9ab-4be4-8fd4-affe9f5535d6/NYUL-Health_logo_Purple_RGB_72ppi.jpg https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/17f49622-592b-4ad0-ab36-8412e846530e/NYUGSOM_logo_Purple_RGB_72ppi.jpg https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/7ac0583e-ae42-4c62-9ed6-ff345e175eed/A_DSC8340_LSaville.jpg https://www.cureadlab.com/donate daily 0.75 2025-01-24 https://www.cureadlab.com/sadowski-lab-news daily 0.75 2025-12-04 https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/03ba7461-20cb-48b3-bc64-3208b4d04082/APOE+Genotype+Differentially+Modulates+Prion+Pathology+in+a+Mouse+Model.png Sadowski Lab News 2026. New publication! APOE genotype differentially modulates prion pathology in a mouse model by Lizinczyk and Pankiewicz et al. https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/a9e948ed-a8c9-4ec2-bbb6-7425a71bb5a8/IMG_7108.jpeg Sadowski Lab News Nov 18 2025. Our Research Associate, William Cullina, presented his poster at the 2025 annual Society for Neuroscience meeting in San Diego. The poster was titled, "Aged APOE ε4-Targeted Replacement Mice Exhibit a Brain Atrophy Dichotomy" https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/1752501552529-OGS87UW81CYAILPCCC3J/IMG_6043.jpg Sadowski Lab News July 11 2025. We were joined by Dr. Paul Mathews and Dr. Efrat Levy for a collaborator's meeting regarding NIH award, "Apolipoprotein E genotype modulates brain mitovesicle production, a component of mitochondrial quality control" (RF1AG088226) https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/2049d439-1e9a-4dc0-a968-0b37717d5ed9/US+News+%26+World+Report.PNG Sadowski Lab News NYU Langone was ranked #1 for Neurology & Neurosurgery by the U.S. News & World Report for the 4th year in a row (2025-2026). https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/1741810965240-M47W0NKKNTRKUETOR32C/unsplash-image-bcqDxjddPGk.jpg Sadowski Lab News Feb 1 2025. New award! Off-the-shelf CAR-Engineered Macrophage Therapy for Alzheimer’s Disease (1R61 AG090384) https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/1741811039648-GBU29BCB66MXQDBUL004/unsplash-image-EAgGqOiDDMg.jpg Sadowski Lab News Sept 1 2024. New award! Apolipoprotein E genotype modulates brain mitovesicle production, a component of mitochondrial quality control (1RF1AG088226) https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/26a483e8-3f2f-4d9b-b3b8-59061ec0327b/Neuronal+Morphogenesis.PNG Sadowski Lab News 2024. New publication! Analysis of Neurite and Spine Formation in Neurons in Vitro by Diaz & Sadowski https://www.cureadlab.com/sadowski-lab-past-projects daily 0.75 2026-03-10 https://www.cureadlab.com/sadowski-lab-current-projects daily 0.75 2026-03-23 https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/b4a856bc-8123-42e8-9752-28b8caf6e1ed/APPx+E2+E3+E4.jpg Sadowski Lab Current Projects APOE genotype is the strongest risk factor for sporadic Alzheimer’s disease. Targeted replacement of the mouse Apoe gene for human APOE alleles in APP/PS1 Alzheimer transgenic model mice demonstrates differential effects of the APOE alleles on Aβ plaque load (Pankiewicz et al., 2017). https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/45a469bf-a60c-4076-b8a8-18930b46d41d/C3+GFAP+Prion.jpg Sadowski Lab Current Projects Astrocytes become neurotoxic under conditions of neurodegeneration, which is vastly exacerbated by the absence of Apoe. This highlights the importance of apoE in preventing the astrocyte transition to a neurotoxic phenotype (Pankiewicz & Lizinczyk et al., 2021). https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/dda6fbdb-e360-4320-b33b-70cf275b34f8/Spines+APOE+genotypes.jpg Sadowski Lab Current Projects Cultured neurons exposed to apoE lipoparticles from APOE ε2, ε3, and ε4 targeted replacement mice illuminate the variable dendritic spine morphology induced by each apoE isoform, which corresponds to accelerated synapse loss seen in ε4 carriers (Diaz et al., 2022). https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/ebaab972-db39-416a-ac73-84889693edf9/X-34+AB+GFAP+Prdx6.jpg Sadowski Lab Current Projects Astrocyte processes are enticed to amyloid plaques and their dense cores in APP/PS1 Alzheimer’s mice with overexpressing peroxiredoxin (PRDX) 6. PRDX6 encourages glial targeting of Aβ (Pankiewicz et al., 2020). https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/6120aa72-089a-4689-bf60-9225c044486e/New+cathespin-prion-merge.jpg Sadowski Lab Current Projects Shown is fluorescently labeled therapeutic anti-PrP mAb 6D11 targeting the PrP-Sc for lysosomal degradation. Treatment of prion infected cells with mAb 6D11 clears them from the presence of PrP-Sc (Pankiewicz et al., 2019) https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/82d2e150-6d11-4b8f-a76c-3c4da5825c19/Prion+Iba1+CD68.jpg Sadowski Lab Current Projects Effective phagocytosis of misfolded proteins by microglia is imperative to counter neurodegeneration. The absence of Apoe limits microglial phagocytosis, which underscores the importance of Apoe in regulating disease-limiting microglial activity (Pankiewicz & Lizinczyk et al., 2021). https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/a40be505-388d-425f-a935-0f2e5d19588e/CAR+Graphic.PNG https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/802ce329-3ad8-4faf-b6c8-bcd46903bac0/Fisher.png https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/d064c10a-0b08-423a-8b2c-0c9ba160cc3e/Apoe+-_-+prion_+neurodegenerative+microglia.png https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/2b4657f9-8a1b-42da-a0be-c23bdd7bfc6a/Diaz+Dendritic+outgrowth.PNG https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/7b385fb0-6b3f-4d31-bfc3-1ad335146a62/PRDX6+AB+and+Glial+Activity.PNG https://www.cureadlab.com/sadowski-lab-overview daily 0.75 2026-03-27 https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/def026c6-4e87-49c5-ba33-b4659b41847b/Sadowski+Lab+Approach+v3.png https://www.cureadlab.com/join-the-sadowski-lab daily 0.75 2026-03-23 https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/cc978292-11cb-40ae-959a-3f9c4d470d5d/TamaraFlemingPhotography_FCARF_TFP_8529+-+Copy.jpg https://images.squarespace-cdn.com/content/v1/6757262bdcdd8144d181bc89/1a327c63-b4dd-419e-a020-4ae8c6ea1932/KP4_HCH+Entrance+Wide_Jeff+Goldberg.jpg